Scientific Lead

Job Description

Welcome to the era of Velsera! Seven Bridges, Pierian UgenTec have combined to become Velsera. Velsera is the precision engine company. We empower researchers, scientists, and clinicians to drive precision RD, expand access to, and more effectively leverage analytics at the point of care. We unify technology-enabled solutions and scientific expertise to enable a continuous flow of knowledge across the global healthcare ecosystem. This interweaves diverse biomedical communities, allowing them to build upon each other s success and accelerate medical breakthroughs that positively impact human health. With our headquarters in Boston, MA, we are growing and expanding our team which located in 14 different countries! Designation: Scientific Lead Location: Pune, India (Hybrid) As a Scientific Lead, you will report to the Manager KB and your tasks will consist of application on strong molecular biology and cancer biology background to curate, interpret and represent data from variety of sources into logical rules that form the core of our clinical genomics knowledgebase. What will you do Technical/Scientific - Demonstrate clear understanding of rules in KB and the rule firing logic. - Association between gene test and clinical findings - Predicates and attributes, how it impacts rule firing. - Patient management impact - Therapeutic / Prognostic / Diagnostic - Understanding of disease ontology and how it impacts rule firing. - In disease/out of disease concept - Understanding of different disease ontologies that is currently used by KB and its implication. - Different Rule firing engines - CGW vs TPS vs Lotus - Variant classification classification hierarchy (precedence logic) - WashU CAP/AMP/ASCO - Demonstrate clear understanding of respective source curation workflow for the given KB team. - Contribute as reviewer of the curated content. - Existing curation strategies and the clinically significant data that is curated. - Understanding of QA/QC process - How the curated data is used downstream and how it impacts patient care. - Create/design workflow for new curation strategy or extrapolate existing curation strategies to a similar new scenario. - Be the content owner of the respective source and be responsible for overall QC/QA of the data curated by the team, ensuring delivery of high-quality data. - Create/design SOPs /or Work Instruction (WI) generation. - Demonstrate new ideas and ability to present and defend ideas in team or CCC meetings. - Problem solving mindset - provide clear solutions or take decisions to resolve blockers in day-to-day tasks and be able to support/justify them in scientifically acceptable way or by providing necessary evidence. - Identify potential risks of process, project or design, and report deviation from SOP or WI - For deviations, we expect impact analysis to be conducted and some solution to be proposed. - Identify gaps or misalignment between written WI and workflow implementation and propose solutions. - Initiate and drive QMS/SQA related discussions to ensure quality compliance of KB content. - Identify tooling requirements/enhancements to improve source curation workflow and initiate discussion with KBMS team. - Have a basic understanding of other KB team s workflow and strategies - SME reviewer for other KB team s annotation WIs - Provide inputs in other team s strategy design. Collaborate wherever possible to increase efficiency and quality of the overall KB product. - Mentorship: provide mentorship to juniors and reviewers on content strategies helping them to scale up. - Thought leadership: You should be seen as a reference and go-to person for niche expertise. - Open to self-training and exploring new technologies. Communications - Should be able to initiate discussions and communicate issues within team or across teams with clear background understanding to achieve outcome or conclusions. - Initiate or engage in clear communication (slack, email, and verbal) regarding any blockers/issues with members of (other) teams, follow-up and conclude. - Ability to develop documentation, power point presentations, flowcharts, diagrams etc. to communicate technical solutions. Operational - Should have a strong sense of ownership urgency. - Follow/execute daily/weekly tasks till completion based on SOP with ownership and responsibility. - Self QC of work - demonstrate a high standard with each deliverable. - Commitment to delivery of day-to-day tasks and projects involved as per the project timelines. - Clear communication of daily work progress/status to the team lead - Decision making: In scenarios where the team is blocked because of some issue/gap, you should be able to provide a logical path forward to the team. - Identify needs, gather supporting evidence to devise or come up with proposals for newer processes/workflows. - Identify ways to increase team velocity and efficiency. For example, identify areas where automation would help and accordingly provide requirements for tool development. - Create plans for projects or processes on their own whenever required. - Plan and execute POC for new projects or sub tasks. - Content documentation - document and review content related approach in scientific and methodical manner - Manage different types of complexities in the workflow. - Trainings. - Design, document and execute existing or revised training workflows and conduct trainings as per SOP/WI - Identify the training needs within the team or specific team member to improve efficiency and quality of the data delivered. - Take a lead in solving problems or small projects, be proactive and own results. - Should provide regular peer feedback to the team/functional leads. - Demonstrate strong adherence to Velsera core values. What do you bring to the table - Ph.D. in genetics, genomics, molecular biology, or an equivalent with 4+ years of postdoc or work experience OR - Master s degree in molecular biology, genetics, biotechnology, or biochemistry with 8+ years of work experience - Genetic and molecular understanding of human disease. - Good understanding of genomic databases and their annotations (For example: GenBank, RefSeq, dbSNP etc.). - Basic understanding of cancer biology and signaling pathways. - An understanding of bioinformatics analysis to identify variants within genomic data sets is desirable. - Proficiency in communicating and understanding of genetic variant details. - An enthusiastic "can-do" mentality with leadership skills, a dedicated team-worker, having good verbal and written communication skills. - Previous experience as an experimental scientist in applied science or hands-on experience in oncogenomic diagnostic laboratories is a big plus. - Experience with open-source bioinformatics tools and publicly available variant databases is a plus. - Personal initiative and ability to work effectively as part of a team. - Excellent communication skills. Our Core Values People first. We create collaborative and supportive environments by operating with respect and flexibility to promote mental, emotional and physical health. We practice empathy by treating others the way they want to be treated and assuming positive intent. We are proud of our inclusive diverse team and humble ourselves to learn about and build our connection with each other. Patient focused. We act with swift determination without sacrificing our expectations of quality . We are driven by providing exceptional solutions for our customers to positively impact patient lives. Considering what is at stake, we challenge ourselves to develop the best solution, not just the easy one. Integrity. We hold ourselves accountable and strive for transparent communication to build trust amongst ourselves and our customers. We take ownership of our results as we know what we do matters and collectively we will change the healthcare industry. We are thoughtful and intentional with every customer interaction understanding the overall impact on human health. Curious. We ask questions and actively listen in order to learn and continuously improve . We embrace change and the opportunities it presents to make each other better. We strive to be on the cutting edge of science and technology innovation by encouraging creativity. Impactful. We take our social responsibility with the seriousness it deserves and hold ourselves to a high standard. We improve our sustainability by encouraging discussion and taking action as it relates to our natural, social and economic resource footprint. We are devoted to our humanitarian mission and look for new ways to make the world a better place. Velsera is an Equal Opportunity Employer: Velsera is proud to be an equal opportunity employer committed to providing employment opportunity regardless of sex, race, creed, colour, gender, religion, marital status, domestic partner status, age, national origin or ancestry.